| First Author | de Knijff P | Year | 1991 |
| Journal | Atherosclerosis | Volume | 90 |
| Issue | 2-3 | Pages | 169-74 |
| PubMed ID | 1836947 | Mgi Jnum | J:3127 |
| Mgi Id | MGI:51642 | Doi | 10.1016/0021-9150(91)90111-f |
| Citation | de Knijff P, et al. (1991) Apolipoprotein E polymorphism affects plasma levels of lipoprotein(a). Atherosclerosis 90(2-3):169-74 |
| abstractText | In a group of 303 healthy Caucasian adults of both sexes we studied the influence of the apolipoprotein E (apo E) polymorphism on plasma levels of Lipoprotein(a) (Lp(a). The APOE*2 allele was found to decrease the mean plasma Lp(a) level by 24.8%, whereas the APOE*4 allele increased the mean Lp(a) level by 25.7%. These effects were parallel to the effect of apo E polymorphism on plasma cholesterol and low density lipoprotein (LDL)-cholesterol. For the Lp(a) levels, the genetic variance associated with the APOE locus contributed about 4% to the total phenotypic variance. For plasma cholesterol and LDL-cholesterol this contribution was 4.5 and 6.3%, respectively. We also found a significant positive correlation between LDL-cholesterol and Lp(a) levels. Since the apo E polymorphism effects LDL-receptor activity, we conclude that, at least in healthy normolipidemic individuals, plasma levels of Lp(a) are modulated by the LDL-receptor activity. |
