| First Author | Grathwohl SA | Year | 2009 |
| Journal | Nat Neurosci | Volume | 12 |
| Issue | 11 | Pages | 1361-3 |
| PubMed ID | 19838177 | Mgi Jnum | J:154603 |
| Mgi Id | MGI:4397613 | Doi | 10.1038/nn.2432 |
| Citation | Grathwohl SA, et al. (2009) Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nat Neurosci 12(11):1361-3 |
| abstractText | In Alzheimer's disease, microglia cluster around beta-amyloid deposits, suggesting that these cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed two distinct APP transgenic mouse strains with CD11b-HSVTK mice, in which nearly complete ablation of microglia was achieved for up to 4 weeks after ganciclovir application. Neither amyloid plaque formation and maintenance nor amyloid-associated neuritic dystrophy depended on the presence of microglia. |
