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Protein Coding Gene : Casp8ap2 caspase 8 associated protein 2
Primary Identifier  MGI:1349399 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  26885
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables cysteine-type endopeptidase activator activity involved in apoptotic process; identical protein binding activity; and protease binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in cytoplasm and nucleus. Predicted to be active in PML body and mitochondrion. Is expressed in several structures, including brain ventricular layer; incisor; inner cell mass; renal calyx; and submandibular gland primordium. Orthologous to human CASP8AP2 (caspase 8 associated protein 2).
PHENOTYPE: Mice homozygous for disruption of this gene die before implantation. [provided by MGI curators]
  • synonyms:
  • D4Ertd659e,
  • caspase 8 associated protein 2,
  • MGI:3034772,
  • MGI:1277118,
  • expressed sequence AA387232,
  • AA387232,
  • FLASH,
  • mKIAA1315,
  • DNA segment, Chr 4, ERATO Doi 659, expressed,
  • Casp8ap2
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

Trail: ProteinCodingGene

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

5 Pathways

Trail: ProteinCodingGene

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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