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Publication : Infectivity of preserved Cryptosporidium parvum oocysts for immunosuppressed adult mice.

First Author  Yang S Year  1996
Journal  FEMS Immunol Med Microbiol Volume  13
Issue  2 Pages  141-5
PubMed ID  8731022 Mgi Jnum  J:33338
Mgi Id  MGI:80819 Doi  10.1016/0928-8244(95)00096-8
Citation  Yang S, et al. (1996) Infectivity of preserved Cryptosporidium parvum oocysts for immunosuppressed adult mice. FEMS Immunol Med Microbiol 13(2):141-5
abstractText  The present study was undertaken to determine the infectivity of Cryptosporidium parvum oocysts for immunosuppressed adult C57BL/6N mice after the oocysts had been stored from 1-48 months at 4 degrees C in 2.5% potassium dichromate. All mice inoculated with oocysts 1-18 months old developed patent infections, while mice inoculated with older oocysts remained uninfected. The prepatent period was extended from 2 to 6 or 7 days as the storage time for oocysts increased. The finding that C. parvum oocysts remain infective for mice for at least 18 months offers important economic and time-saving advantages for investigators who frequently require large numbers of oocysts that must be painstakingly purified from calf manure.
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