Primary Identifier | MGI:1923294 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 76044 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables bHLH transcription factor binding activity. Involved in positive regulation of chromosome segregation and positive regulation of chromosome separation. Acts upstream of with a positive effect on erythrocyte differentiation. Acts upstream of with a negative effect on transcription by RNA polymerase II. Acts upstream of or within inner cell mass cell proliferation. Located in condensed nuclear chromosome. Part of condensin complex. Is active in nucleus. Is expressed in several structures, including axial musculature; brain; hemolymphoid system; liver; and nasal cavity epithelium. Orthologous to human NCAPG2 (non-SMC condensin II complex subunit G2). PHENOTYPE: Homozygous null embryos exhibit impaired inner cell mass expansion and die shortly after implantation and prior to gastrulation and blood cell development. [provided by MGI curators] |