| First Author | Fossat N | Year | 2014 |
| Journal | EMBO Rep | Volume | 15 |
| Issue | 8 | Pages | 903-10 |
| PubMed ID | 24916387 | Mgi Jnum | J:217130 |
| Mgi Id | MGI:5613094 | Doi | 10.15252/embr.201438450 |
| Citation | Fossat N, et al. (2014) C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47. EMBO Rep 15(8):903-10 |
| abstractText | Cytidine (C) to Uridine (U) RNA editing is a post-transcriptional modification that is accomplished by the deaminase APOBEC1 and its partnership with the RNA-binding protein A1CF. We identify and characterise here a novel RNA-binding protein, RBM47, that interacts with APOBEC1 and A1CF and is expressed in tissues where C to U RNA editing occurs. RBM47 can substitute for A1CF and is necessary and sufficient for APOBEC1-mediated editing in vitro. Editing is further impaired in Rbm47-deficient mutant mice. These findings suggest that RBM47 and APOBEC1 constitute the basic machinery for C to U RNA editing. |
