| Primary Identifier | MGI:1346870 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 26399 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables MAP kinase kinase activity. Involved in bone development; negative regulation of cold-induced thermogenesis; and osteoblast differentiation. Acts upstream of or within MAPK cascade; cardiac muscle contraction; and positive regulation of MAPK cascade. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Orthologous to human MAP2K6 (mitogen-activated protein kinase kinase 6). PHENOTYPE: Mice homozygous for null targeted mutations of this gene are viable, grow normally and have no gross physical or histologic abnormalities. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
