| Primary Identifier | MGI:1346878 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 26410 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in gap junction-mediated intercellular transport. Predicted to act upstream of or within immune system process and phosphorylation. Predicted to be located in cytosol. Is expressed in several structures, including adipose tissue; adrenal gland; alimentary system; hemolymphoid system gland; and reproductive system. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma and stomach cancer. Orthologous to human MAP3K8 (mitogen-activated protein kinase kinase kinase 8). PHENOTYPE: Mutant mice resist endotoxic shock. Their MHC II expression is enhanced. Macrophages' TNF-alpha response to viruses and to all TLR ligands is impaired. Macrophage and T-cell secretion of other cytokines in response to various TLR ligands or OVA is aberrant. Anti-OVA Ig classes are abnormally skewed. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
