| Primary Identifier | MGI:96113 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 15289 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables cytokine activity; nucleic acid binding activity; and protein kinase regulator activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of signal transduction; and positive regulation of sprouting angiogenesis. Acts upstream of or within several processes, including cellular response to interleukin-7; positive regulation of cell differentiation; and positive regulation of macromolecule metabolic process. Located in several cellular components, including early endosome; extracellular space; and neuron projection. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and retina. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and congestive heart failure. Orthologous to human HMGB1 (high mobility group box 1). PHENOTYPE: Homozygous null mice display partial or complete neonatal lethality due to hypoglycemia depending on the strain background, with open eyelids at birth, atelectasis, and lethargy. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
