| First Author | Moreau-Gachelin F | Year | 1989 |
| Journal | Oncogene | Volume | 4 |
| Issue | 12 | Pages | 1449-56 |
| PubMed ID | 2594367 | Mgi Jnum | J:10149 |
| Mgi Id | MGI:58605 | Citation | Moreau-Gachelin F, et al. (1989) The putative oncogene Spi-1: murine chromosomal localization and transcriptional activation in murine acute erythroleukemias [published erratum appears in Oncogene 1990 Jun;5(6):941]. Oncogene 4(12):1449-56 |
| abstractText | We have shown previously that spleen focus forming virus integration near the Spi-1 putative oncogene is observed in 95% of erythroid Friend tumors (Moreau-Gachelin et al., 1988). Here we describe how the proviral insertion in the Spi-1 domain is associated with the enhanced transcription of a 1.4 kb mRNA normally expressed at a low level in normal cells. The gene is localized on murine chromosome 2, band E3. The structure of the Spi-1 gene was determined by sequencing genomic and cDNA clones. The gene has an open reading frame encoding a protein of 218 amino acids, extending over five exons. Proviruses always integrate outside, upstream and in the opposite orientation of the protein-encoding domain. This suggests that SFFV integration activates the expression of Spi-2 gene that may contribute to the erythroleukemic process. |
