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Protein Domain : Saccharopine dehydrogenase, NADP binding domain

Primary Identifier  IPR005097 Type  Domain
Short Name  Sacchrp_dh_NADP
description  This entry represents the NADP binding domain of saccharopine dehydrogenase. In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase. The saccharopine dehydrogenase can also function as a saccharopine reductase [, ].Saccharopine dehydrogenase () catalyses the condensation of l-alpha-aminoadipate-delta-semialdehyde (AASA) with l-glutamate to give an imine, which is reduced by NADPH to give saccharopine []. In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase (PF). Saccharopine dehydrogenase can also function as a saccharopine reductase. Saccharopine is an intermediate in lysine metabolism.Homospermidine synthase (HSS) () catalyses the synthesis of the polyamine homospermidine from 2 putrescine molecules in an NAD+-dependent reaction []. HSS evolved from the alternative spermidine biosynthetic pathway enzyme carboxyspermidine dehydrogenase [, ]and the structure of HSS is related to lysine metabolic enzymes [].

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7 Protein Domain Regions