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Protein Coding Gene : Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1

Primary Identifier  MGI:96247 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  15516
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables protein folding chaperone; protein kinase binding activity; and tau protein binding activity. Contributes to protein kinase regulator activity. Involved in several processes, including cellular response to heat; negative regulation of proteasomal protein catabolic process; and protein folding. Acts upstream of or within cellular response to interleukin-4; negative regulation of apoptotic process; and placenta development. Located in growth cone; neuronal cell body; and perinuclear region of cytoplasm. Part of HSP90-CDC37 chaperone complex. Is expressed in several structures, including branchial arch; central nervous system; eye; jaw; and limb. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to several human genes including HSP90AB1 (heat shock protein 90 alpha family class B member 1).
PHENOTYPE: Homozygotes for a gene-trapped null mutation exhibit placental defects including failure to form a placental labyrinth and lack of expansion of allantoic blood vessels. Mutants die around mid-gestation. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-10974,
  • Hsp84-1,
  • expressed sequence AL022974,
  • AL022974,
  • Hsp84,
  • MGI:2146951,
  • heat shock protein, 84 kDa 1,
  • expressed sequence C81438,
  • Hsp90ab1,
  • Hspcb,
  • heat shock protein, 90 kDa,
  • heat shock protein 1, beta,
  • heat shock protein 90 alpha (cytosolic), class B member 1,
  • MGI:2147140,
  • Hsp90,
  • C81438,
  • MGD-MRK-10963

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