| First Author | Benveniste P | Year | 2010 |
| Journal | Cell Stem Cell | Volume | 6 |
| Issue | 1 | Pages | 48-58 |
| PubMed ID | 20074534 | Mgi Jnum | J:157080 |
| Mgi Id | MGI:4429995 | Doi | 10.1016/j.stem.2009.11.014 |
| Citation | Benveniste P, et al. (2010) Intermediate-term hematopoietic stem cells with extended but time-limited reconstitution potential. Cell Stem Cell 6(1):48-58 |
| abstractText | Sustained blood cell production depends on divisions by hematopoietic stem cells (HSCs) that yield both differentiating progeny as well as new HSCs via self-renewal. Differentiating progeny remain capable of self-renewal, but only HSCs sustain self-renewal through successive divisions securely enough to maintain clones that persist life-long. Until recently, the first identified next stage consisted of 'short-term' reconstituting cells able to sustain clones of differentiating cells for only 4-6 weeks. Here we expand evidence for a numerically dominant 'intermediate-term' multipotent HSC stage in mice whose clones persist for 6-8 months before becoming extinct and that are separable from both short-term as well as permanently reconstituting 'long-term' HSCs. The findings suggest that the first step in stem cell differentiation consists not in loss of initial capacity for serial self-renewal divisions, but rather in loss of mechanisms that stabilize self-renewing behavior throughout successive future stem cell divisions. |
