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Publication : Deuterosome-mediated centriole biogenesis.

First Author  Klos Dehring DA Year  2013
Journal  Dev Cell Volume  27
Issue  1 Pages  103-12
PubMed ID  24075808 Mgi Jnum  J:203425
Mgi Id  MGI:5527014 Doi  10.1016/j.devcel.2013.08.021
Citation  Klos Dehring DA, et al. (2013) Deuterosome-mediated centriole biogenesis. Dev Cell 27(1):103-12
abstractText  The ability of cells to faithfully duplicate their two centrioles once per cell cycle is critical for proper mitotic progression and chromosome segregation. Multiciliated cells represent an interesting variation of centriole duplication in that these cells generate greater than 100 centrioles, which form the basal bodies of their motile cilia. This centriole amplification is proposed to require a structure termed the deuterosome, thought to be capable of promoting de novo centriole biogenesis. Here, we begin to molecularly characterize the deuterosome and identify it as a site for the localization of Cep152, Plk4, and SAS6. Additionally we identify CCDC78 as a centriole-associated and deuterosome protein that is essential for centriole amplification. Overexpression of Cep152, but not Plk4, SAS6, or CCDC78, drives overamplification of centrioles. However, in CCDC78 morphants, Cep152 fails to localize to the deuterosome and centriole biogenesis is impaired, indicating that CCDC78-mediated recruitment of Cep152 is required for deuterosome-mediated centriole biogenesis.
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