| Primary Identifier | IPR006129 | Type | Family |
| Short Name | AdhesinB |
| description | The Streptococcus pneumoniae psaA gene encodes a protein with significant similarity to previously-reported Streptococcal proteins, SsaB (80% similarity) and FimA (92.3% similarity), from Streptococcus sanguis and Streptococcus parasanguis []. These homologues are associated with bacterial adhesion, and PsaA may play a similar role [].The SsaB protein has a putative hydrophobic 19-amino-acid signal sequence yielding a 32,620-Mr secreted protein []. SsaB is hydrophilic and appears not to have a hydrophobic membrane anchor in its C-terminal region. A high degree of similarity exists between S. sanguis ssaB and type 1 fimbrial genes []. Comparison of the gene products reveals close similarity of the two proteins. It is thought that ssaB adhesion may play a role in oral colonisation by binding either to a receptor on saliva or to a receptor on Actinomyces.This sub-family is described by from conserved regions spanning the full alignmentlength, focusing on those sections that characterise the adhesin Bprecursors but distinguish them from the rest of the adhesin family. |
