| Primary Identifier | IPR003923 | Type | Family |
| Short Name | TFIID_30kDa |
| description | Transcription initiation factor TFIID is a multimeric protein complex thatplays a central role in mediating promoter responses to various activatorsand repressors. The complex includes TATA binding protein (TBP) and variousTBP-associated factors (TAFS). TFIID is a bona fide RNA polymerase II-specificTATA-binding protein-associated factor (TAF) and is essential for viability []. This entry represents one of the TAFs, TAF10.TFIID acts to nucleate the transcription complex, recruiting the rest ofthe factors through a direct interaction with TFIIB. The TBP subunit of TFIID is sufficient for TATA-element binding and TFIIB interaction, and can support basal transcription. The protein belongs to the TAF2H family.TAF10 is part of other transcription regulatory multiprotein complexes (e.g., SAGA, TBP-free TAF-containing complex [TFTC], STAGA, and PCAF/GCN5). Several TAFs interact via histone-fold motifs. The histone fold (HFD) is the interaction motif involved in heterodimerization of the core histones and their assembly into nucleosome octamer. The minimal HFD contains three α-helices linked by two loops. The HFD is found in core histones, TAFs and many other transcription factors. Five HF-containing TAF pairs have been described in TFIID: TAF6-TAF9, TAF4-TAF12, TAF11-TAF13, TAF8-TAF10 and TAF3-TAF10 [, , ]. |
