| First Author | Labeur M | Year | 2010 |
| Journal | Mol Cell Endocrinol | Volume | 326 |
| Issue | 1-2 | Pages | 85-8 |
| PubMed ID | 20398728 | Mgi Jnum | J:163203 |
| Mgi Id | MGI:4821232 | Doi | 10.1016/j.mce.2010.04.006 |
| Citation | Labeur M, et al. (2010) Pituitary tumors: cell type-specific roles for BMP-4. Mol Cell Endocrinol 326(1-2):85-8 |
| abstractText | BMP-4 plays a crucial role not only in the formation of the anterior pituitary during embryo development but also in the pathogenesis of pituitary tumors in adults. In tumor cells, BMP-4 promotes prolactin secretion and lactotroph cell proliferation through a Smad-estrogen receptor crosstalk but it inhibits ACTH production and cell proliferation of corticotrophs. In addition, BMP-4 increases GH secretion in rat pituitary tumor somatolactotroph GH3 cells and FSHbeta subunit gene transcription in the murine gonadotroph cell line, LbetaT2. Therefore, BMP-4 has a differential role on different types of pituitary tumors: it promotes pituitary prolactinoma while it inhibits corticotroph pathogenesis in Cushing's disease. The modulation of BMP-4 also plays an important role in the therapeutic mechanism of action of bromocriptine, somatostatin analogs and retinoic acid. |
