| First Author | Law M | Year | 2015 |
| Journal | J Immunol | Volume | 195 |
| Issue | 2 | Pages | 426-30 |
| PubMed ID | 26056254 | Mgi Jnum | J:242810 |
| Mgi Id | MGI:5906551 | Doi | 10.4049/jimmunol.1401442 |
| Citation | Law M, et al. (2015) Cutting Edge: Drebrin-Regulated Actin Dynamics Regulate IgE-Dependent Mast Cell Activation and Allergic Responses. J Immunol 195(2):426-30 |
| abstractText | Mast cells play critical roles in allergic responses. Calcium signaling controls the function of these cells, and a role for actin in regulating calcium influx into cells has been suggested. We have previously identified the actin reorganizing protein Drebrin as a target of the immunosuppressant 3,5-bistrifluoromethyl pyrazole, which inhibits calcium influx into cells. In this study, we show that Drebrin(-/-) mice exhibit reduced IgE-mediated histamine release and passive systemic anaphylaxis, and Drebrin(-/-) mast cells also exhibit defects in FcepsilonRI-mediated degranulation. Drebrin(-/-) mast cells exhibit defects in actin cytoskeleton organization and calcium responses downstream of the FcepsilonRI, and agents that relieve actin reorganization rescue mast cell FcepsilonRI-induced degranulation. Our results indicate that Drebrin regulates the actin cytoskeleton and calcium responses in mast cells, thus regulating mast cell function in vivo. |
