| First Author | Kawagishi H | Year | 2008 |
| Journal | EMBO J | Volume | 27 |
| Issue | 10 | Pages | 1481-90 |
| PubMed ID | 18418387 | Mgi Jnum | J:136258 |
| Mgi Id | MGI:3795801 | Doi | 10.1038/emboj.2008.76 |
| Citation | Kawagishi H, et al. (2008) Hzf regulates adipogenesis through translational control of C/EBPalpha. EMBO J 27(10):1481-90 |
| abstractText | Adipocyte differentiation requires a well-defined programme of gene expression in which the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein) has a central function. Here, we show that Hzf (haematopoietic zinc-finger), a previously identified p53 transcriptional target, regulates C/EBPalpha expression. Hzf is induced during differentiation of preadipocyte cell lines, and its suppression by short hairpin RNA disrupts adipogenesis. In Hzf's absence, expression of C/EBPalpha is severely impaired because of reduced translation of its mRNA. Hzf physically interacts with the 3' untranslated region of C/EBPalpha mRNA to enhance its translation. Taken together, these findings underscore a critical role of Hzf in the adipogenesis regulatory cascade. |
