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Protein Coding Gene : Ift25 intraflagellar transport 25
Primary Identifier  MGI:1920188 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  72938
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable metal ion binding activity. Involved in kidney development; smoothened signaling pathway; and spermatogenesis. Acts upstream of or within several processes, including left/right axis specification; lung development; and skeletal system development. Located in centrosome and cilium. Part of intraciliary transport particle B. Is expressed in embryo; germ cell of ovary; and secondary heart field. Orthologous to human IFT25 (intraflagellar transport 25).
PHENOTYPE: Homozygous null mice show fetal growth retardation and complete neonatal death due to severe structural heart defects. Omphalocele, polydactyly, left pulmonary isomerism, and skeletal defects such as micrognathia, cleft palate, malaligned sternal vertebrae, and a small rib cage are often observed. [provided by MGI curators]
  • synonyms:
  • 2900042B11Rik,
  • RIKEN cDNA 2900042B11 gene,
  • heat shock protein family B (small), member 11,
  • intraflagellar transport 25,
  • Hspb11,
  • Ift25
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Features --> Cross References

Genome

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4 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

3 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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