| First Author | Flory CM | Year | 1992 |
| Journal | J Leukoc Biol | Volume | 51 |
| Issue | 3 | Pages | 225-9 |
| PubMed ID | 1347311 | Mgi Jnum | J:12681 |
| Mgi Id | MGI:60917 | Doi | 10.1002/jlb.51.3.225 |
| Citation | Flory CM, et al. (1992) Effects of in vivo T lymphocyte subset depletion on mycobacterial infections in mice. J Leukoc Biol 51(3):225-9 |
| abstractText | The relative importance of CD4+ and CD8+ T cell subsets in the expression of acquired resistance to systemic infection by Mycobacterium kansasii was determined. T cell subsets were depleted in thymectomized C57BL/6 mice by the intravenous administration of monoclonal antibodies directed against the relevant T cell determinants. Depletion of the CD4+ subset exacerbated the severity of the infection in intravenously challenged mice. This effect was apparent in the first 2 weeks of the infection and persisted throughout the 12 weeks of the study. On the other hand, depletion of the CD8+ cells had no apparent effect on the growth curves. Infections by Mycobacterium tuberculosis Erdman or bacille Calmette-Guerin (BCG) Pasteur were also substantially enhanced by CD4 depletion, but not by the depletion of CD8+ cells. The effect of subset depletion on infections by M. tuberculosis and BCG was examined in both innately susceptible C57BL/6 mice and innately resistant B6D2 mice. |
