| Primary Identifier | IPR039384 | Type | Family |
| Short Name | HINT |
| description | HINT (histidine triad nucleotide-binding protein) are related to the HIT family members that carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid) []. On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the FHIT branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases []. HINT family includes members from all three forms of cellular life. In budding yeast Hnt1 has been shown to have adenosine monophosphoramidase activity []. It is involved in secretion, peroxisome formation and gene expression [, ]. The bacterial and archaeal members of this family are mostly uncharacterised. |
