| Primary Identifier | MGI:1916017 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 68767 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables gamma-tubulin binding activity and phosphatidylinositol 3-kinase inhibitor activity. Involved in several processes, including Arp2/3 complex-mediated actin nucleation; meiotic nuclear division; and oocyte maturation. Acts upstream of or within several processes, including low-density lipoprotein particle clearance; positive regulation of cholesterol import; and positive regulation of protein localization to cell surface. Located in autophagosome; centrosome; and endosome. Part of BLOC-1 complex and WASH complex. Is expressed in several structures, including brain; genitourinary system; immune system; liver; and lung. Orthologous to several human genes including WASHC1 (WASH complex subunit 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit lethality prior to E7.5 with increased cell death and autophagy. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
