| First Author | Vanhalst K | Year | 2005 |
| Journal | Cell Mol Life Sci | Volume | 62 |
| Issue | 11 | Pages | 1247-59 |
| PubMed ID | 15905963 | Mgi Jnum | J:99267 |
| Mgi Id | MGI:3581914 | Doi | 10.1007/s00018-005-5021-7 |
| Citation | Vanhalst K, et al. (2005) delta-Protocadherins: a gene family expressed differentially in the mouse brain. Cell Mol Life Sci 62(11):1247-59 |
| abstractText | Phylogenetic analysis of protocadherin genes identified a new gene subfamily, the delta-protocadherins, containing several conserved motifs in their cytoplasmic domains. This subfamily can be further subdivided into two subgroups, named delta1-protocadherins (comprising protocadherin-1, -7, -9, and -11 or X/Y) and delta2-protocadherins (comprising protocadherin-8, -10, -17, -18, and -19). The members of the delta1-protocadherin subgroup were analyzed in greater detail here. They share a similar gene structure that results in the expression of multiple alternative transcripts. All members of this subgroup have at least one transcript that contains a binding site for protein phosphatase-1alpha. Like most classic cadherins, each of three delta1-protocadherins analyzed in this study by in situ hybridization showed a unique expression pattern that differed from the patterns of the other delta1-protocadherins. Together, these results suggest that the members of the delta1-protocadherin subgroup exercise tightly regulated functions in the development, regionalization, and functional differentiation of the mouse brain. |
