| Primary Identifier | IPR030714 | Type | Family |
| Short Name | Protocadherin-18 |
| description | Protocadherin-18 (Pcdh18) belongs to the delta-2 subfamily of nonclustered protocadherins (comprising protocadherin-8, -10, -17, -18, and -19) []. Zebrafish has two Pcdh18 isoforms, Pcdh18a and Pcdh18b. Pcdh18a has a role in cell adhesion and migration [], whereas Pcdh18b interacts with Nap1, an important regulator of actin dynamics, to control motor axon growth and arborisation in primary motoneurons []. In mouse, Pcdh18 interacts with Disabled-1 (Dab1) and may play a role during brain development [].The cadherin family consists of a large group of cell adhesion proteins. It can be classified into three subfamilies: classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Based on the genomic structure, the PCDH family can be divided into two groups, clustered PCDHs and non-clustered PCDHs. Non-clustered PCDHs can be further classified into three subgroups: delta1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), delta2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and epsilon (PCDH15, PCDH16, PCDH21 and MUCDHL). Non-clustered PCDHs are expressed predominantly in the nervous system and have spatiotemporally diverse expression patterns []. |
