| First Author | Burda P | Year | 2010 |
| Journal | Leukemia | Volume | 24 |
| Issue | 7 | Pages | 1249-57 |
| PubMed ID | 20520638 | Mgi Jnum | J:162250 |
| Mgi Id | MGI:4818515 | Doi | 10.1038/leu.2010.104 |
| Citation | Burda P, et al. (2010) The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis. Leukemia 24(7):1249-57 |
| abstractText | Hematopoiesis is coordinated by a complex regulatory network of transcription factors and among them PU.1 (Spi1, Sfpi1) represents a key molecule. This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein-protein interactions with additional factors. The mutual negative regulation between PU.1 and GATA-1 is detailed within the context of normal and leukemogenic hematopoiesis and the concept of 'differentiation therapy' to restore normal cellular differentiation of leukemic cells is discussed. |
