| Type | MGI:General | Description | at 12 months of age, mice accumulate significant amounts of total heparan sulfate (HS) in brain, kidney and spleen, with the highest total HS amount found in kidney (5x) HS exhibits glucuronate-2-O-sulfated non-reducing ends (NREs) particularly in brain and kidney; recombinant ARSK/GDS efficiently degrades the glucuronate-2-O-sulfated NREs of accumulated HS although total chondroitin sulfate (CS) is elevated in the kidney (5x), liver homogenates and purified liver lysosomes exhibit normal CS levels |
