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Allele : Tg(CAG-GBA*L483P)8Clk transgene insertion 8, Lorne A Clarke
Primary Identifier  MGI:6209788 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(CAG-GBA*L483P)8Clk
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  The transgenic construct contains the human GBA gene under the direction of the CMV enhancer/chicken beta-actin promoter, rabbit B-globin intron sequence and the rabbit globin polyA site (pCAGEN) promoter. GBA was modified by site-directed mutagenesis (c.1448T>C) to harbor an leucine to proline mutation at residue 483 (described as L444P).
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • hL444P,
  • hL444P
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

2 Publication categories

Trail: Allele




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