| Primary Identifier | MGI:1922967 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 75717 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase binding activity. Acts upstream of or within cerebral cortex radially oriented cell migration; protein ubiquitination; and radial glia guided migration of Purkinje cell. Predicted to be located in site of DNA damage. Predicted to be part of Cul5-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Is expressed in several structures, including brain; eye; genitourinary system; gut; and limb bud. Orthologous to human CUL5 (cullin 5). PHENOTYPE: Mice homozygous for a null allele exhibit complete embryonic lethality. Mice heterozygous for a null allele exhibit decreased susceptibility to LPS-induced lung injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
