| Primary Identifier | MGI:1347360 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 26554 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables cyclin binding activity and identical protein binding activity. Involved in several processes, including embryonic cleavage; integrin-mediated signaling pathway; and regulation protein catabolic process at postsynapse. Acts upstream of or within with a positive effect on protein polyubiquitination. Acts upstream of or within several processes, including embryonic morphogenesis; fibroblast apoptotic process; and liver morphogenesis. Located in Golgi apparatus; nucleus; and postsynapse. Is active in glutamatergic synapse. Is expressed in several structures, including cerebral cortex; extraembryonic component; gonad; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human CUL3 (cullin 3). PHENOTYPE: Homozygotes for a targeted null mutation accumulate cyclin E, exhibit abnormal cycling in cells of extraembryonic ectoderm and trophectoderm, reduced size, abnormal gastrulation and trophoblast cells, absence of an amnion, and death by embryonic day 7.5. Conditional heterozygous KO in neuronal cells causes social deficits and anxiety-like behavior, while homozygous neuronal KO leads to brain abnormalities, small body size and death before weaning. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
