| First Author | Hall JA | Year | 2011 |
| Journal | Immunity | Volume | 34 |
| Issue | 3 | Pages | 435-47 |
| PubMed ID | 21419664 | Mgi Jnum | J:169861 |
| Mgi Id | MGI:4943364 | Doi | 10.1016/j.immuni.2011.03.003 |
| Citation | Hall JA, et al. (2011) Essential Role for Retinoic Acid in the Promotion of CD4(+) T Cell Effector Responses via Retinoic Acid Receptor Alpha. Immunity 34(3):435-47 |
| abstractText | Vitamin A and its metabolite, retinoic acid (RA) are implicated in the regulation of immune homeostasis via the peripheral induction of regulatory T cells. Here we showed RA was also required to elicit proinflammatory CD4(+) helper T cell responses to infection and mucosal vaccination. Retinoic acid receptor alpha (RARalpha) was the critical mediator of these effects. Antagonism of RAR signaling and deficiency in RARalpha (Rara(-/-)) resulted in a cell-autonomous CD4(+) T cell activation defect, which impaired intermediate signaling events, including calcium mobilization. Altogether, these findings reveal a fundamental role for the RA-RARalpha axis in the development of both regulatory and inflammatory arms of adaptive immunity and establish nutritional status as a broad regulator of adaptive T cell responses. |
