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Protein Coding Gene : Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)

Primary Identifier  MGI:1346527 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  16913
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable endopeptidase activity. Involved in fat cell differentiation. Acts upstream of or within antigen processing and presentation. Part of proteasome core complex and spermatoproteasome complex. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in proteasome-associated autoinflammatory syndrome 1. Orthologous to human PSMB8 (proteasome 20S subunit beta 8).
PHENOTYPE: Mice homozygous for disruptions in this gene display an essentially normal phenotype. However they have a reduced ability to process MHC class I restricted antigens. [provided by MGI curators]
  • synonyms:
  • Lmp-7,
  • MGD-MRK-11824,
  • Psmb8,
  • Lmp7,
  • low molecular weight polypeptide 7,
  • large multifunctional protease 7,
  • MGD-MRK-11822,
  • proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7),
  • MGI:96798

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

3 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For