| First Author | Marchitto MC | Year | 2019 |
| Journal | Proc Natl Acad Sci U S A | Volume | 116 |
| Issue | 22 | Pages | 10917-10926 |
| PubMed ID | 31088972 | Mgi Jnum | J:275883 |
| Mgi Id | MGI:6307182 | Doi | 10.1073/pnas.1818256116 |
| Citation | Marchitto MC, et al. (2019) Clonal Vgamma6(+)Vdelta4(+) T cells promote IL-17-mediated immunity against Staphylococcus aureus skin infection. Proc Natl Acad Sci U S A 116(22):10917-10926 |
| abstractText | T cell cytokines contribute to immunity against Staphylococcus aureus, but the predominant T cell subsets involved are unclear. In an S. aureus skin infection mouse model, we found that the IL-17 response was mediated by gammadelta T cells, which trafficked from lymph nodes to the infected skin to induce neutrophil recruitment, proinflammatory cytokines IL-1alpha, IL-1beta, and TNF, and host defense peptides. RNA-seq for TRG and TRD sequences in lymph nodes and skin revealed a single clonotypic expansion of the encoded complementarity-determining region 3 amino acid sequence, which could be generated by canonical nucleotide sequences of TRGV5 or TRGV6 and TRDV4 However, only TRGV6 and TRDV4 but not TRGV5 sequences expanded. Finally, Vgamma6(+) T cells were a predominant gammadelta T cell subset that produced IL-17A as well as IL-22, TNF, and IFNgamma, indicating a broad and substantial role for clonal Vgamma6(+)Vdelta4(+) T cells in immunity against S. aureus skin infections. |
