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Protein Coding Gene : Pde6a phosphodiesterase 6A, cGMP-specific, rod, alpha
Primary Identifier  MGI:97524 Organism  mouse, laboratory
Chromosome  18 NCBI Gene Number  225600
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Acts upstream of or within photoreceptor cell maintenance and retina development in camera-type eye. Predicted to be located in plasma membrane. Predicted to be active in photoreceptor outer segment membrane. Is expressed in eye; retina; and retina outer nuclear layer. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in retinitis pigmentosa 43. Orthologous to human PDE6A (phosphodiesterase 6A).
PHENOTYPE: Homozygous mutant mice have retinal degeneration. [provided by MGI curators]
  • synonyms:
  • neuroscience mutagenesis facility, 282,
  • Pdea,
  • Pde6a,
  • phosphodiesterase 6A, cGMP-specific, rod, alpha,
  • MGI:3611305,
  • nmf282,
  • MGD-MRK-13208
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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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9 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

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Phenotype

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