| Type | MGI:General | Description | filaggrin protein and mRNA levels are significantly reduced whereas involucrin is up-regulated both at protein and mRNA levels; loricrin levels remain unchanged despite a reduction observed in L-granule size ceramides and glucosylceramides (GlcCer) are completely absent in the stratum corneum both polar and nonpolar lipids are significantly reduced in the stratum corneum, with a more prominent reduction noted in nonpolar lipids (ceramides) lipids exhibit a dot-like distribution, unlike the weave-like distribution seen in wild-type controls in vitro, primary keratinocytes isolated from P0.5 show a reduction in nonpolar lipids after 3 days of differentiation |
