| Primary Identifier | MGI:102687 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 12044 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable BH domain binding activity; channel activity; and protein dimerization activity. Involved in negative regulation of apoptotic process. Acts upstream of or within B cell homeostasis and negative regulation of B cell apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including bone; central nervous system; heart; hemolymphoid system; and respiratory system. Orthologous to human BCL2A1 (BCL2 related protein A1). PHENOTYPE: Homozygous null mutants show enhanced spontaneous apoptosis of neutrophils, while both heterozygous and homozygous null mutants lack LPS-induced neutrophil apoptosis inhibition. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
