| First Author | Wiejak J | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 9 | Pages | 1556-61 |
| PubMed ID | 24631457 | Mgi Jnum | J:208646 |
| Mgi Id | MGI:5563873 | Doi | 10.1016/j.febslet.2014.02.038 |
| Citation | Wiejak J, et al. (2014) The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs. FEBS Lett 588(9):1556-61 |
| abstractText | The cyclic AMP sensor, EPAC1, activates AP1-mediated transcription in HUVECs. Correspondingly, induction of the SOCS3 minimal promoter by EPAC1 requires a single AP1 site that constitutively binds phosphorylated (Ser63) c-Jun in DNA-pull-down assays. c-Jun (Ser63) becomes further phosphorylated following cyclic AMP stimulation and specific activation of protein kinase A (PKA), but not through selective activation of EPAC1. Moreover, despite a requirement for c-Jun for SOCS3 induction in fibroblasts, phospho-null c-Jun (Ser63/73Ala) had little effect on SOCS3 induction by cyclic AMP in HUVECs. AP1 activation and SOCS3 induction by EPAC1 in HUVECs therefore occur independently of c-Jun phosphorylation on Ser63. |
