| First Author | Bedoui S | Year | 2009 |
| Journal | Nat Immunol | Volume | 10 |
| Issue | 5 | Pages | 488-95 |
| PubMed ID | 19349986 | Mgi Jnum | J:272549 |
| Mgi Id | MGI:6258980 | Doi | 10.1038/ni.1724 |
| Citation | Bedoui S, et al. (2009) Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells. Nat Immunol 10(5):488-95 |
| abstractText | Skin-derived dendritic cells (DCs) include Langerhans cells, classical dermal DCs and a langerin-positive CD103(+) dermal subset. We examined their involvement in the presentation of skin-associated viral and self antigens. Only the CD103(+) subset efficiently presented antigens of herpes simplex virus type 1 to naive CD8(+) T cells, although all subsets presented these antigens to CD4(+) T cells. This showed that CD103(+) DCs were the migratory subset most efficient at processing viral antigens into the major histocompatibility complex class I pathway, potentially through cross-presentation. This was supported by data showing only CD103(+) DCs efficiently cross-presented skin-derived self antigens. This indicates CD103(+) DCs are the main migratory subtype able to cross-present viral and self antigens, which identifies another level of specialization for skin DCs. |
