| Primary Identifier | MGI:2146320 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 210293 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in B cell homeostasis; dendritic spine morphogenesis; and marginal zone B cell differentiation. Located in dendritic spine. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including central nervous system; endocrine gland; retina; thymus primordium; and trigeminal nerve. Orthologous to human DOCK10 (dedicator of cytokinesis 10). PHENOTYPE: Mice homozygous for a knock-out allele exhibit a reduction of B cell numbers in secondary lymphoid organs. Follicular B cells show membrane CD23 overexpression. Homozygous KO also leads to a thinner spleen marginal zone B cell region and a decreased thymic CD8+ T cell percentage. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
