| First Author | Imhof A | Year | 2006 |
| Journal | Neurobiol Dis | Volume | 22 |
| Issue | 2 | Pages | 274-83 |
| PubMed ID | 16473512 | Mgi Jnum | J:111243 |
| Mgi Id | MGI:3653326 | Doi | 10.1016/j.nbd.2005.11.009 |
| Citation | Imhof A, et al. (2006) Sustained astrocytic clusterin expression improves remodeling after brain ischemia. Neurobiol Dis 22(2):274-83 |
| abstractText | Clusterin is a glycoprotein highly expressed in response to tissue injury. Using clusterin-deficient (Clu-/-) mice, we investigated the role of clusterin after permanent middle cerebral artery occlusion (MCAO). In wild-type (WT) mice, clusterin mRNA displayed a sustained increase in the peri-infarct area from 14 to 30 days post-MCAO. Clusterin transcript was still present up to 90 days post-ischemia in astrocytes surrounding the core infarct. Western blot analysis also revealed an increase of clusterin in the ischemic hemisphere of WT mice, which culminates up to 30 days post-MCAO. Concomitantly, a worse structural restoration and higher number of GFAP-reactive astrocytes in the vicinity of the infarct scar were observed in Clu-/- as compared to WT mice. These findings go beyond previous data supporting a neuroprotective role of clusterin in early ischemic events in that they demonstrate that this glycoprotein plays a central role in the remodeling of ischemic damage. |
