| Primary Identifier | IPR038491 | Type | Homologous_superfamily |
| Short Name | Velvet_dom_sf |
| description | The fungus-specific velvet family of regulatory proteins plays a key role incoordinating secondary metabolism and differentiation processes such asasexual or sexual sporulation and sclerotia or fruiting body formation. Thesevelvet regulators are present in most parts of the fungal kingdom fromchytrids to basidiomycetes. Velvet proteins interact with each other, alone("homodimers"), in various combinations ("heterodimers"), and also with otherproteins. The velvet proteins share a homologous region comprising about 150amino acids, which lack significant sequence similarity to any other knownproteins. The velvet domain is involved in specific DNA binding as well as inthe dimerization of the different velvet proteins, resulting in the formationof homo- and heterodimers [, ].The velvet domain is an RHD-like domain related to NF-kappaB. It folds into a highly twisted β-sandwich composed of sevenantiparallel β-strands. One side of the β-sandwich isinvolved in dimer formation, whereas the other one is flanked by several loopsof which two fold into an α-helix. These α-helical fragments arelocated between β-strands 2 and 3 and at the C terminus [, ]. |
