| First Author | Yokode M | Year | 1990 |
| Journal | Science | Volume | 250 |
| Issue | 4985 | Pages | 1273-5 |
| PubMed ID | 2244210 | Mgi Jnum | J:128413 |
| Mgi Id | MGI:3767039 | Doi | 10.1126/science.2244210 |
| Citation | Yokode M, et al. (1990) Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors. Science 250(4985):1273-5 |
| abstractText | The current studies were designed to determine whether chronic overexpression of low density lipoprotein (LDL) receptors in the liver would protect mice from the increase in plasma LDL-cholesterol that is induced by high-fat diets. A line of transgenic mice was studied that express the human LDL receptor gene in the liver under control of the transferrin promoter. When fed a diet containing cholesterol, saturated fat, and bile acids for 3 weeks, the transgenic mice, in contrast to normal mice, did not develop a detectable increase in plasma LDL. The current data indicate that unregulated overexpression of LDL receptors can protect against diet-induced hypercholesterolemia in mice. |
