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Allele : Mlkl<em2Xidw> mixed lineage kinase domain-like; endonuclease-mediated mutation 2, Xiaodong Wang
Primary Identifier  MGI:7447137 Allele Type  Endonuclease-mediated
Gene  Mlkl Strain of Origin  C57BL/6J
Is Recombinase  false Is Wild Type  false
molecularNote  CRISPR/Cas9 technology generated a TCC to GCT change resulting in a serine to alanine substitution at amino acid 441 (p.S441A). Two synonymous mutations were also introduced to avoid Cas9 cleavage.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • MLKL S441A,
  • MLKL S441A
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1 Feature

Trail: Allele

Genome

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0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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