| First Author | Sawa Y | Year | 2009 |
| Journal | Immunity | Volume | 30 |
| Issue | 3 | Pages | 447-57 |
| PubMed ID | 19285437 | Mgi Jnum | J:147058 |
| Mgi Id | MGI:3839178 | Doi | 10.1016/j.immuni.2009.01.007 |
| Citation | Sawa Y, et al. (2009) Hepatic interleukin-7 expression regulates T cell responses. Immunity 30(3):447-57 |
| abstractText | Systemic cytokine activity in response to Toll-like receptor (TLR) signaling induces the expression of various proteins in the liver after infections. Here we show that Interleukin-7 (IL-7), the production of which was thought to occur at a constant rate in vivo, was a hepatically expressed protein that directly controled T cell responses. Depletion of IL-7 expression in the liver abrogated several TLR-mediated T cell events, including enhanced CD4+ T cell and CD8+ T cell survival, augmented CD8+ T cell cytotoxic activity, and the development of experimental autoimmune encephalitis, a Th17 cell-mediated autoimmune disease. Thus, T cell responses are regulated by hepatocyte-derived IL-7, which is expressed in response to TLR signaling in vivo. We suggested that TLR-induced IL-7 expression in the liver, which is an acute-phase response, may be a good diagnostic and therapeutic target for efficient vaccine developments and for conditions characterized by TLR-mediated T cell dysregulation, including autoimmune diseases. |
