| First Author | Altman BJ | Year | 2012 |
| Journal | FEBS J | Volume | 279 |
| Issue | 15 | Pages | 2598-609 |
| PubMed ID | 22672505 | Mgi Jnum | J:201032 |
| Mgi Id | MGI:5510657 | Doi | 10.1111/j.1742-4658.2012.08651.x |
| Citation | Altman BJ, et al. (2012) Normal and cancer cell metabolism: lymphocytes and lymphoma. FEBS J 279(15):2598-609 |
| abstractText | Recent studies of normal and neoplastic lymphocytes have revealed overlapping metabolic rewiring in activated T cells and Myc-transformed lymphocytes. Myc expression is attenuated in normal lymphocytes that return to the basal state, but Notch-activated or Myc-transformed lymphocytes persistently express Myc, which activates genes involved in glucose and glutamine metabolism. Although this difference could provide a therapeutic window for the treatment of cancers, the overlapping metabolic profiles suggest a potential for immunosuppression by metabolic inhibitors. |
