| Primary Identifier | MGI:1915756 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 67087 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables beta-catenin binding activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of smooth muscle cell proliferation; and negative regulation of transcription initiation by RNA polymerase II. Acts upstream of or within anterior/posterior pattern specification; branching involved in ureteric bud morphogenesis; and negative regulation of Wnt signaling pathway. Part of beta-catenin-ICAT complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human CTNNBIP1 (catenin beta interacting protein 1). PHENOTYPE: Homozygous null mice display neonatal lethality associated with rupture of the gut, posteriorized neural cell fate within the neural plate, abnormal craniofacial morphology, and renal agenesis due to arrest of ureteric bud branching. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
