| First Author | Wegrzyn J | Year | 2009 |
| Journal | Science | Volume | 323 |
| Issue | 5915 | Pages | 793-7 |
| PubMed ID | 19131594 | Mgi Jnum | J:144505 |
| Mgi Id | MGI:3831048 | Doi | 10.1126/science.1164551 |
| Citation | Wegrzyn J, et al. (2009) Function of mitochondrial Stat3 in cellular respiration. Science 323(5915):793-7 |
| abstractText | Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that results in activation of Stat3-responsive genes. We provide evidence that Stat3 is present in the mitochondria of cultured cells and primary tissues, including the liver and heart. In Stat3(-/-) cells, the activities of complexes I and II of the electron transport chain (ETC) were significantly decreased. We identified Stat3 mutants that selectively restored the protein's function as a transcription factor or its functions within the ETC. In mice that do not express Stat3 in the heart, there were also selective defects in the activities of complexes I and II of the ETC. These data indicate that Stat3 is required for optimal function of the ETC, which may allow it to orchestrate responses to cellular homeostasis. |
