Primary Identifier | MGI:6448092 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Tnfrsf1a |
Transmission | Germline | Strain of Origin | 129S/SvEv-Gpi1<c> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A targeting vector was designed to delete 15 nucleotides in exon 6 encoding amino acids 202-206. Southern blot and PCR confirmed recombination. Flow cytometry of peritoneal cells indicated that the mutation abolished receptor shedding. |