| Primary Identifier | MGI:1202304 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 14711 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables glycine N-methyltransferase activity and glycine binding activity. Involved in S-adenosylmethionine metabolic process and protein homotetramerization. Acts upstream of or within several processes, including glycogen metabolic process; one-carbon metabolic process; and regulation of gluconeogenesis. Predicted to be located in cytoplasm. Predicted to be part of methyltransferase complex. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; integumental system; limb; sensory organ; and skeleton. Used to study glycine N-methyltransferase deficiency and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in glycine N-methyltransferase deficiency. Orthologous to human GNMT (glycine N-methyltransferase). PHENOTYPE: Mice homozygous for a null mutation display elevated levels of methionine and S-adenosylmethionine in the liver. Mice homozygous for another null allele exhibit hepatitis, increased hepatic glycogen storage, and hepatocellular carcinoma. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
