| First Author | Morrissette DA | Year | 2009 |
| Journal | J Biol Chem | Volume | 284 |
| Issue | 10 | Pages | 6033-7 |
| PubMed ID | 18948253 | Mgi Jnum | J:147920 |
| Mgi Id | MGI:3842903 | Doi | 10.1074/jbc.R800030200 |
| Citation | Morrissette DA, et al. (2009) Relevance of transgenic mouse models to human Alzheimer disease. J Biol Chem 284(10):6033-7 |
| abstractText | During the past 2 decades, the elucidation of susceptibility and causative genes for Alzheimer disease as well as proteins involved in the pathogenic process has greatly facilitated the development of genetically altered mouse models. These models have played a major role in defining critical disease-related mechanisms and in evaluating novel therapeutic approaches, with many treatments currently in clinical trial owing their origins to studies initially performed in mice. This review discusses the utility of transgenic mice as a research tool and their contributions to our understanding of Alzheimer disease. |
